Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
phoQ	K123Q	-	single resistance variant, two-component system sensor histidine kinase PhoQ	Pseudomonas aeruginosa	colistin	Card DatabaseReference Gene Catalog	Confirmed
phoQ sensor histidine kinase	K46E	-	neutral	Klebsiella pneumoniae	colistin	Reslit	Candidate
phoQ Two-component system sensor kinase	K46Q	-	disrupts the phosphatase domain, allowing continuous PhoP activation of downstream genes such as those that modify lipid A, thereby providing colistin resistance	Klebsiella pneumoniae	colistin	Reslit	Candidate
phoQ transmembrane protein	K46T	-	deleterious	Escherichia coli	colistin	Reslit	Candidate
phoQ sensor histidine kinase	L105Q	-	deleterious	Klebsiella pneumoniae	colistin	Reslit	Candidate
phoQ histidine kinase	L10R	-	-	-	colistin	Reslit	Candidate
phoQ histidine kinase	L224Q	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
phoQ histidine kinase	L239P	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
phoQ histidine kinase	L257P	-	-	Klebsiella pneumoniae	colistin	Reslit	Candidate
phoQ two-component system sensor kinase	L26P	-	two-component system sensor histidine kinase PhoQ	Klebsiella pneumoniae	colistin	Reference Gene CatalogReslit	Confirmed