Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
pncA pyrazinamidase/nicotinamidase | A102V | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed | |
pncA pyrazinamidase | A106V | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
pncA pyrazinamidase | A107G | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
pncA pyrazinamidase | A121D | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
pncA pyrazinamidase/nicotinamidase | A134D | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
pncA pyrazinamidase/nicotinamidase | A134P | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed | |
pncA pyrazinamidase | A134R | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
pncA pyrazinamidase | A134T | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
pncA pyrazinamidase | A134V | - | loss of PZAse activity, disrupts catalytic activity, single resistance variant | Mycobacterium tuberculosis, Mycobacterium bovis | pyrazinamide | Card DatabaseReslit | Confirmed |
| A143D | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established |
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