Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
pncA pyrazinamidase | A46T | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
pncA pyrazinamidase | A46V | single resistance variant | Mycobacterium tuberculosis | pyrazinamidepza | Card DatabaseReslit | Confirmed | |
| A79P | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
| A89V | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
| A92E | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
pncA pyrazinamidase | A92P | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
pncA pyrazinamidase/nicotinamidase | C104R | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| C138* | - | nonsense mutation | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
pncA pyrazinamidase | C138A | - | disrupts catalytic activity | Mycobacterium tuberculosis, Mycobacterium bovis | pyrazinamide | Reslit | Candidate |
| C138F | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established |
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