Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
pncA pyrazinamidase | E181K | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed | |
| E37* | - | nonsense mutation | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
pncA pyrazinamidase | E504D | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| E91* | - | nonsense mutation | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
pncA pyrazinamidase/nicotinamidase | E91Q | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
pncA pyrazinamidase | F106L | - | single resistance variant | Mycobacterium tuberculosis | pzapyrazinamide | Card DatabaseReslit | Confirmed |
pncA pyrazinamidase | F106S | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| F106Y | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
| F13I | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
pncA pyrazinamidase | F13L | - | disrupts substrate binding and catalytic activity, single resistance variant | Mycobacterium tuberculosis, Mycobacterium bovis | pyrazinamide | Card DatabaseReslit | Confirmed |
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