Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
pncA pyrazinamidase | L35P | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
pncA pyrazinamidase | L35R | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| L4* | - | nonsense mutation | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
| L4F | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
pncA pyrazinamidase | L4S | - | loss of PZAse activity, single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| L4V | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established | |
pncA pyrazinamidase | L4W | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
pncA pyrazinamidase | L76P | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
pncA pyrazinamidase | L85P | loss of PZAse activity, single resistance variant | Mycobacterium tuberculosis | pyrazinamidepza | Card DatabaseReslit | Confirmed | |
| L85Q | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established |
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