A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA.

PMID: 100228251999

Key Findings

The E26K mutation abolishes resistance to positively charged drugs but retains chloramphenicol resistance.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mdfA	E26K	-	-	Escherichia coli	Chloramphenicol	Reslit	-