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Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus.

PMID: 104289011999

Key Findings

mutation in gyrA gene

0gene entries

6mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S87F	-	confers resistance	Staphylococcus aureus	Fluoroquinolones	Reslit	-
grlA	S80F	-	mutations in grlA (Ser80→Phe or Tyr) were most commonly selected with trovafloxacin, ciprofloxacin, levofloxacin, or pefloxacin	Staphylococcus aureus	Ciprofloxacin\|Levofloxacin\|Sparfloxacin\|Pefloxacin	Reslit	-
grlA	S80Y	-	mutations in grlA (Ser80→Phe or Tyr) were most commonly selected with trovafloxacin, ciprofloxacin, levofloxacin, or pefloxacin	Staphylococcus aureus	Ciprofloxacin\|Levofloxacin\|Sparfloxacin\|Pefloxacin	Reslit	-
gyrA	S84L	-	confers resistance	Staphylococcus aureus	Ciprofloxacin\|Levofloxacin\|Sparfloxacin\|Pefloxacin	Reslit	-
grlA	E84K	-	mutations in grlA (Ser80→Phe or Tyr) were most commonly selected with trovafloxacin, ciprofloxacin, levofloxacin, or pefloxacin	Staphylococcus aureus	Ciprofloxacin\|Levofloxacin\|Sparfloxacin\|Pefloxacin	Reslit	-
gyrA	G81C	-	confers resistance	Staphylococcus aureus	Fluoroquinolones	Reslit	-