High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae.

PMID: 106393632000

Key Findings

The study identifies that high-level resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae is due to high-level expression of chromosomally encoded SHV-1 beta-lactamase and a decrease in a minor outer membrane protein.

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1gene entry

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaSHV	1	beta-lactamase	CeftazidimePiperacillin/tazobactam	Klebsiella pneumoniae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaSHV-1	-	A2C	-	Klebsiella pneumoniae	Ceftazidime\|Piperacillin/tazobactam	Reslit	-
blaSHV	-	C-112A	blaSHV promoter region	Klebsiella pneumoniae	CEFIDEROCOL/CEPHALOSPORIN	Reference Gene Catalog	-

Browse Papers

High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae.

AMR Genes

AMR Mutations