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The extended-spectrum K1 beta-lactamase from Klebsiella oxytoca SC 10,436 is a member of the bla(OXY-2) family of chromosomal Klebsiella enzymes.

PMID: 120191422002

Key Findings

The promoter region mutations enhance hydrolytic activity against monobactams.

4gene entries

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaOXY	1	extended-spectrum class A beta-lactamase OXY-2-8	TICARCILLINCEPHALOSPORINAMOXICILLINCEFOXITINTICARCILLIN+CLAVULANIC ACIDAMPICILLIN+CLAVULANIC ACIDAMPICILLINCEFOTAXIMECEFTAZIDIME+3 more	Klebsiella oxytoca	Card DatabaseReference Gene CatalogResFinder Database	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaOXY-2	G20S	-	enhanced hydrolytic activity against monobactams	Klebsiella oxytoca	-	Reslit	-
blaOXY-2	D197N	-	enhanced hydrolytic activity against monobactams	Klebsiella oxytoca	-	Reslit	-