Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.

PMID: 122708192002

Key Findings

The study identifies that an mtrR mutation leads to overexpression of the MtrC-MtrD-MtrE efflux pump, which is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae. Additionally, insertional inactivation of mtrD reduces resistance to penicillin and tetracycline.

View on PubMed

2gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mtrD	1	membrane transporter component of the MtrC-MtrD-MtrE efflux system	penicillintetracycline	Neisseria gonorrhoeae	Reslit	-
mtrr	1	transcriptional repressor of MtrCDE expression	penicillintetracycline	Neisseria gonorrhoeae	Reslit	-

Browse Papers

Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.

AMR Genes