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gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.

PMID: 123843452002

0gene entries

15mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrB	R447L	-	DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB, single resistance variant	Clostridium difficile, Clostridioides difficile, Clostridium ljungdahlii	Ciprofloxacin\|MoxifloxacinQUINOLONEFluoroquinolones	ReslitReference Gene CatalogCard Database	-
gyrA	D71V	-	single resistance variant	Clostridium difficile, Clostridioides difficile	Ciprofloxacin\|MoxifloxacinFluoroquinolones	ReslitCard Database	-
gyrA	T82I	-	DNA gyrase subunit A GyrA, single resistance variant	Clostridium difficile, Clostridioides difficile	Ciprofloxacin\|MoxifloxacinQUINOLONEFluoroquinolones	ReslitReference Gene CatalogCard Database	-
gyrA	A118T	-	DNA gyrase subunit A GyrA, single resistance variant	Clostridium difficile, Clostridioides difficile	Ciprofloxacin\|MoxifloxacinQUINOLONEFluoroquinolones	ReslitReference Gene CatalogCard Database	-
gyrB	D426N	-	DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB, single resistance variant	Clostridium difficile, Clostridioides difficile, Clostridium ljungdahlii	Ciprofloxacin\|MoxifloxacinQUINOLONEFluoroquinolones	ReslitReference Gene CatalogCard Database	-
gyrA	T82V	-	single resistance variant	Clostridioides difficile	Fluoroquinolones	Card Database	-