Patterns of resistance associated with integrons, the extended-spectrum beta-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak.

PMID: 126240462003The Netherlands

Key Findings

The study identifies the SHV-5 extended-spectrum beta-lactamase gene and a gyrA mutation (Ser83Tyr) as key resistance mechanisms in a multidrug-resistant Klebsiella pneumoniae outbreak. The SHV-5 gene conferred resistance to ceftazidime and aztreonam, while the gyrA mutation contributed to ciprofloxacin resistance.

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1gene entry

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaSHV	1	beta-lactamase	CeftazidimeAztreonam	Klebsiella pneumoniae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	S83Y	-	-	Klebsiella pneumoniae	Ciprofloxacin	Reslit	-

Browse Papers

Patterns of resistance associated with integrons, the extended-spectrum beta-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak.

AMR Genes

AMR Mutations