ATP-bound conformation of topoisomerase IV: a possible target for quinolones in Streptococcus pneumoniae.

PMID: 145260262003

Key Findings

The His103Tyr mutation was found to confer resistance to fluoroquinolones when associated with a mutation in the QRDR of GyrA.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parE	H103Y	CAT->TAT	-	Streptococcus pneumoniae	Moxifloxacin\|Sparfloxacin\|Grepafloxacin	Reslit	-