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Explore scientific publications on antimicrobial resistance

Activities of garenoxacin against quinolone-resistant Streptococcus pneumoniae strains in vitro and in a mouse pneumonia model.

PMID: 149827622004

Key Findings

Mutation in parE leads to quinolone resistance

0gene entries

5mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parE	I460V	-	-	Streptococcus pneumoniae	Ciprofloxacin\|Garenoxacin\|Sparfloxacin\|Trovafloxacin	Reslit	-
gyrA	S81Y	-	-	Streptococcus pneumoniae	Ciprofloxacin\|Garenoxacin\|Sparfloxacin\|Trovafloxacin	Reslit	-
parC	S79Y	-	-	Streptococcus pneumoniae	Ciprofloxacin\|Garenoxacin\|Sparfloxacin\|Trovafloxacin	Reslit	-
parC	S79F	-	-	Streptococcus pneumoniae	Ciprofloxacin\|Garenoxacin\|Sparfloxacin\|Trovafloxacin	Reslit	-
parE	D435N	-	-	Streptococcus pneumoniae	Ciprofloxacin\|Garenoxacin\|Sparfloxacin\|Trovafloxacin	Reslit	-