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Key Findings
The study identifies the bcrABD operon and the regulatory gene bcrR as essential for acquired bacitracin resistance in Enterococcus faecalis. The bcrABD genes encode a homodimeric ABC transporter that mediates bacitracin efflux, and bcrR acts as a transcriptional activator of this operon.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| bcrA | 1 | ATP-binding domain of a homodimeric ABC transporter | Bacitracin |
| Reslit | - |
| bcrB | 1 | membrane-spanning domain of a homodimeric ABC transporter | Bacitracin |
| Reslit | - |
| bcrD | 1 | undecaprenol kinase | Bacitracin |
|
Reslit |
| - |
| bcrR | 1 | novel regulatory protein | Bacitracin |
| Reslit | - |
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