bla(SHV) Genes in Klebsiella pneumoniae: different allele distributions are associated with different promoters within individual isolates.
PMID: 156163032005Australia
Key Findings
The study identifies blaSHV alleles with mutations at codons 238 and 240 that confer resistance to extended-spectrum beta-lactam antibiotics in Klebsiella pneumoniae isolates.
1gene entry
2mutation entries
AMR Genes
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| blaSHV | 1 | beta-lactamase | ceftazidimecefotaximeaztreonam |
| Reslit | - |
AMR Mutations
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| blaSHV | E240K | - | confers extended-spectrum beta-lactamase (ESBL) activity | Klebsiella pneumoniae | ceftazidime|cefotaxime|aztreonam | Reslit | - |
| blaSHV | G238S | - | confers extended-spectrum beta-lactamase (ESBL) activity | Klebsiella pneumoniae | ceftazidime|cefotaxime|aztreonam | Reslit | - |