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Acquisition of rifabutin resistance by a rifampicin resistant mutant of Mycobacterium tuberculosis involves an unusual spectrum of mutations and elevated frequency.

PMID: 159581672005

Key Findings

Mutations in the rpoB gene were identified through sequencing of gene fragments.

0gene entries

8mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	S522L	-	-	Mycobacterium tuberculosis	Rifampicin	Reslit	-
rpoB	F505L	-	-	Mycobacterium tuberculosis	Rifabutin	Reslit	-
rpoB	H526Y	-	-	Mycobacterium tuberculosis	Rifampicin\|Rifabutin	Reslit	-
rpoB	V146F	-	-	Mycobacterium tuberculosis	Rifabutin	Reslit	-
rpoB	S531L	-	-	Mycobacterium tuberculosis	Rifampicin\|Rifabutin	Reslit	-
rpoB	Q148H	-	-	Mycobacterium tuberculosis	Rifabutin	Reslit	-
rpoB	S512G	-	-	Mycobacterium tuberculosis	Rifabutin	Reslit	-
rpoB	V144M	-	-	Mycobacterium tuberculosis	Rifabutin	Reslit	-