The CiaRH system of Streptococcus pneumoniae prevents lysis during stress induced by treatment with cell wall inhibitors and by mutations in pbp2x involved in beta-lactam resistance.

PMID: 164842082006

Key Findings

The T230→P mutation in ciaH activates the CiaRH system, leading to resistance to cefotaxime.

0gene entries

1mutation entry

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ciaH	T230P	-	activates the CiaRH system	Streptococcus pneumoniae	Cefotaxime	Reslit	-