Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae.

PMID: 169400682006

Key Findings

The G545S mutation in penA was identified as a key mutation contributing to reduced susceptibility to cefixime and other cephems.

0gene entries

4mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA	G545S	-	-	Neisseria gonorrhoeae	Cefixime\|Ceftibuten\|Cefepime\|Ceftriaxone	Reslit	-
pbp2	V316T	-	single resistance variant	Neisseria meningitidis	Beta-lactams	Card Database	-
pbp2	G545S	-	single resistance variant	Neisseria meningitidis	Beta-lactams	Card Database	-
pbp2	I312M	-	single resistance variant	Neisseria meningitidis	Beta-lactams	Card Database	-