Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.

PMID: 186518412008

Key Findings

Mutations in the mshA gene, which is involved in mycothiol biosynthesis, confer co-resistance to isoniazid and ethionamide in Mycobacterium tuberculosis.

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1gene entry

5mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mshA	1	glycosyltransferase	Ethionamide	Mycobacterium tuberculosis	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mshA	G299C	-	Loss of function	Mycobacterium tuberculosis	Ethionamide	Reslit	-
mshA	E361A	-	Loss of function	Mycobacterium tuberculosis	Ethionamide	Reslit	-
mshA	G356D	-	Loss of function	Mycobacterium tuberculosis	Ethionamide	Reslit

Browse Papers

Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.

AMR Genes

AMR Mutations