Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes.

PMID: 204041162010Japan

Key Findings

The study identified two novel plasmid-mediated fosfomycin-modifying enzymes, FosA3 and FosC2, which inactivate fosfomycin through glutathione S-transferase activity.

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6gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
fosA	2	glutathione S-transferase	FosfomycinFOSFOMYCIN	Escherichia coli	ResFinder DatabaseReslit	-
fosC2	1	glutathione S-transferase	FosfomycinFOSFOMYCIN	Escherichia coli	Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Browse Papers

Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes.

AMR Genes