Should moxifloxacin be used for the treatment of extensively drug-resistant tuberculosis? An answer from a murine model.

PMID: 208053882010

Key Findings

Mutations in gyrA were associated with increased MICs for fluoroquinolones.

0gene entries

3mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA	A90V	-	mutations in the gyrA and/or gyrB subunit of DNA gyrase lead to fluoroquinolone resistance	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-
gyrA	D94G	-	mutations in the gyrA and/or gyrB subunit of DNA gyrase lead to fluoroquinolone resistance	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-
gyrB	D500N	-	-	Mycobacterium tuberculosis	Fluoroquinolones	Reslit	-