Opening of the outer membrane protein channel in tripartite efflux pumps is induced by interaction with the membrane fusion partner.

PMID: 211154812011

Key Findings

Mutations in the intra-protomer groove of MtrE lead to increased susceptibility to antibiotics.

0gene entries

9mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mtrE	K397E	-	-	Escherichia coli	Vancomycin	Reslit	-
mtrE	Q441E	C1323G	-	Escherichia coli	Vancomycin	Reslit	-
mtrE	E434K	G1301A	-	Escherichia coli	Vancomycin	Reslit	-
mtrE	R239E	-	-	Escherichia coli	Vancomycin	Reslit	-
mtrE	N198L	AAC->CTC AAG->CTG	-	Escherichia coli	Vancomycin	Reslit	-