Compensatory evolution of pbp mutations restores the fitness cost imposed by β-lactam resistance in Streptococcus pneumoniae.

PMID: 213795702011Argentina

Key Findings

The study identifies pbp2b, pbp2x, and pbp1a mutations as conferring β-lactam resistance in Streptococcus pneumoniae, with compensatory mutations restoring fitness costs.

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3gene entries

2mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
pbp1a	1	penicillin-binding protein 1a	Cefotaxime	Streptococcus pneumoniae	Reslit	-
pbp2b	1	penicillin-binding protein 2b	Penicillin	Streptococcus pneumoniae	Reslit	-
pbp2x	1	penicillin-binding protein 2x	Cefotaxime	Streptococcus pneumoniae

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp2b	E285Q	-	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime\|Piperacillin	Reslit	-
pbp2x	N278D	-	-	Streptococcus pneumoniae	Penicillin\|Cefotaxime\|Piperacillin	Reslit	-

Browse Papers

Compensatory evolution of pbp mutations restores the fitness cost imposed by β-lactam resistance in Streptococcus pneumoniae.

AMR Genes

AMR Mutations