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Key Findings
Mutations in acrR were found to lead to AcrAB overexpression, contributing to tigecycline resistance.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| T5N | - | - | Klebsiella pneumoniae | Tigecycline | Reslit | - | |
| L214F | - | - | Klebsiella pneumoniae | Tigecycline | Reslit | - | |
| E147E | - | - | Klebsiella pneumoniae | Tigecycline | Reslit | - | |
| P155P | - | - | Klebsiella pneumoniae | Tigecycline | Reslit | - | |
| A19V | - | TetR/AcrR family transcriptional regulator RamR | Klebsiella pneumoniae | TIGECYCLINE | Reference Gene Catalog | - |
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