The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by MacB transporter.

PMID: 216964642011

0gene entries

3mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
macA	G357A	-	modest effect on the MP domain of MacA	Escherichia coli	Erythromycin\|Oleandomycin	Reslit	-
macA	G353A	-	disrupts the proper assembly of the MacA-MacB complex	Escherichia coli	Erythromycin\|Oleandomycin	Reslit	-
macA	-	G353A	reduces resistance to macrolides in vivo	Escherichia coli	Macrolide	Reslit	-