High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure.

PMID: 221558302012France

Key Findings

The study identifies a novel penA mosaic allele, penA-CI, which confers high-level resistance to ceftriaxone and cefixime in Neisseria gonorrhoeae strain F89. This allele was experimentally validated through transformation and MIC testing.

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1gene entry

6mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
penA	1	penicillin-binding protein 2	CeftriaxoneCefixime	Neisseria gonorrhoeae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA	A311V	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	CEPHALOSPORIN	Reference Gene Catalog	-
penA	I312M	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	CEPHALOSPORIN	Reference Gene Catalog	-
penA	V316T	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	CEPHALOSPORIN

Browse Papers

High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure.

AMR Genes

AMR Mutations