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Explore scientific publications on antimicrobial resistance
Explore scientific publications on antimicrobial resistance
Key Findings
The study identifies RarA, a novel AraC-family transcriptional regulator in Klebsiella pneumoniae, which contributes to multidrug resistance by upregulating the oqxAB efflux pump. Overexpression of RarA leads to increased MICs for multiple antibiotics, including chloramphenicol, tetracycline, ciprofloxacin, norfloxacin, tigecycline, and olaquindox.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| rarA | 1 | transcriptional regulator | ChloramphenicolTetracyclineCiprofloxacinNorfloxacinTigecyclineOlaquindox |
| Reslit | - |
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| F6S | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | - | |
| Q11L | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | - | |
| V113I | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae |
NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE |
Reference Gene Catalog |
| - |
| D95E | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | - |
| V130R | - | Rrf2 family transcriptional regulator OqxR | Klebsiella pneumoniae | NITROFURANTOIN/PHENICOL/QUINOLONE/TIGECYCLINE | Reference Gene Catalog | - |
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