The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L.

PMID: 232544342013

Key Findings

The study identifies the cfr gene, which encodes a methyltransferase targeting 23S rRNA, as a major contributor to high linezolid resistance in Staphylococcus epidermidis isolate 426-3147L. Additionally, mutations in 23S rRNA (C2534T) and ribosomal proteins L3 and L4 were found to contribute to the resistance.

View on PubMed

1gene entry

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
cfr	1	RNA methyltransferase	Linezolid	Staphylococcus epidermidis	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rrl	-	C2534T	-	Staphylococcus epidermidis	Linezolid	Reslit	-

Browse Papers

The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L.

AMR Genes

AMR Mutations