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Identification of amino acids conferring high-level resistance to expanded-spectrum cephalosporins in the penA gene from Neisseria gonorrhoeae strain H041.

PMID: 235879462013

Key Findings

The mutations A311V, T316P, and T483S in the penA gene of Neisseria gonorrhoeae strain H041 confer high-level resistance to expanded-spectrum cephalosporins.

0gene entries

10mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA	T483S	-	confers high-level resistance to expanded-spectrum cephalosporins, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	Ceftizoxime\|CeftriaxoneCEPHALOSPORIN	ReslitReference Gene Catalog	-
penA	T316P	-	confers high-level resistance to expanded-spectrum cephalosporins	Neisseria gonorrhoeae	Ceftizoxime\|Ceftriaxone	Reslit	-
penA	A311V	-	confers high-level resistance to expanded-spectrum cephalosporins	Neisseria gonorrhoeae	Ceftizoxime\|Ceftriaxone	Reslit	-
penA	I312M	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	CEPHALOSPORIN	Reference Gene Catalog	-
penA	V316P	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	CEPHALOSPORIN	Reference Gene Catalog	-
penA	V316T	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	CEPHALOSPORIN	Reference Gene Catalog	-
pbp2	T483S	-	single resistance variant	Neisseria gonorrhoeae	Beta-lactams	Card Database	-
pbp2	A311V	-	single resistance variant	Neisseria gonorrhoeae	Beta-lactams	Card Database	-
pbp2	V316P	-	single resistance variant	Neisseria gonorrhoeae	Beta-lactams	Card Database	-