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Alterations of gyrA, gyrB, and parC and Activity of Efflux Pump in Fluoroquinolone-resistant Acinetobacter baumannii.

PMID: 241594682011

Key Findings

Mutation S80L in parC was observed in some isolates.

0gene entries

10mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	S80L	-	-	Acinetobacter baumannii	Ciprofloxacin\|Gemifloxacin\|Levofloxacin\|Norfloxacin\|Gatifloxacin	Reslit	-
gyrB	A677V	-	-	Acinetobacter baumannii	Ciprofloxacin\|Gemifloxacin\|Levofloxacin\|Norfloxacin\|Gatifloxacin	Reslit	-
gyrA	S83L	-	-	Acinetobacter baumannii	Ciprofloxacin\|Gemifloxacin\|Levofloxacin\|Norfloxacin\|Gatifloxacin	Reslit	-
parC	S80W	-	-	Acinetobacter baumannii	Ciprofloxacin\|Gemifloxacin\|Levofloxacin\|Norfloxacin\|Gatifloxacin	Reslit	-
gyrB	E679D	-	-	Acinetobacter baumannii	Ciprofloxacin\|Gemifloxacin\|Levofloxacin\|Norfloxacin\|Gatifloxacin	Reslit	-
parC	E84K	-	-	Acinetobacter baumannii	Ciprofloxacin\|Gemifloxacin\|Levofloxacin\|Norfloxacin\|Gatifloxacin	Reslit	-
gyrB	D644Y	-	-	Acinetobacter baumannii	Ciprofloxacin\|Gemifloxacin\|Levofloxacin\|Norfloxacin\|Gatifloxacin	Reslit	-
parC	S84F	-	DNA topoisomerase IV subunit A ParC	Acinetobacter baumannii	QUINOLONE	Reference Gene Catalog	-
parC	E88K	-	DNA topoisomerase IV subunit A ParC	Acinetobacter baumannii	QUINOLONE	Reference Gene Catalog	-
parC	S84W	-	DNA topoisomerase IV subunit A ParC	Acinetobacter baumannii	QUINOLONE	Reference Gene Catalog	-