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Key Findings
The study identifies plasmid-mediated oqxAB as an important mechanism for nitrofurantoin resistance in Escherichia coli, demonstrating that the presence of oqxAB increases nitrofurantoin resistance and that its removal significantly reduces resistance.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| oqxab | 1 | efflux pump | Nitrofurantoin |
| Reslit | - |
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| K141Ter | - | nitroreductase NfsA, nonsense mutation | Escherichia coli | NITROFURANTOINNitrofurantoin | Reference Gene CatalogCard Database | - | |
| Q44Ter | - | nitroreductase NfsA, nonsense mutation | Escherichia coli | NITROFURANTOINNitrofurantoin | Reference Gene CatalogCard Database | - | |
| R133S |
| - |
| nitroreductase NfsA, single resistance variant |
| Escherichia coli |
NITROFURANTOINNitrofurantoin |
Reference Gene CatalogCard Database |
| - |
| E223Ter | - | nitroreductase NfsA | Escherichia coli | NITROFURANTOIN | Reference Gene Catalog | - |
| E233Ter | - | nonsense mutation | Escherichia coli | Nitrofurantoin | Card Database | - |
| E137Ter | - | nonsense mutation | Escherichia coli | Nitrofurantoin | Card Database | - |
© 2026 ResLit. Data sourced from PubMed literature analysis.
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