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Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins.

PMID: 276901212016

Key Findings

Mutations in penA contribute to β-lactam resistance in Neisseria spp.

0gene entries

32mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA	F504L	-	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria meningitidis, Neisseria gonorrhoeae	Ceftriaxone\|CefiximeCEPHALOSPORIN	ReslitReference Gene Catalog	-
penA	H541N	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	Penicillin	Reslit	-
penA	V316T	-	reduced reactivity for β-lactams	Neisseria meningitidis, Neisseria gonorrhoeae	Ceftriaxone\|Cefixime	Reslit	-
penA	A501V	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	Ceftriaxone\|Cefixime	Reslit	-
penA	P551S	-	reduced reactivity for β-lactams	Neisseria meningitidis, Neisseria gonorrhoeae	Ceftriaxone\|Cefixime	Reslit	-
penA	V316P	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	Ceftriaxone\|Cefixime	Reslit	-
penA	A510V	-	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	Ceftriaxone\|CefiximeCEPHALOSPORIN	ReslitReference Gene Catalog	-
penA	G545S	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	Ceftriaxone\|Cefixime	Reslit	-
penA	G482S	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	Ceftriaxone\|Cefixime	Reslit	-
penA	I312M	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	Ceftriaxone\|Cefixime	Reslit	-
penA	A501P	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	Ceftriaxone\|Cefixime	Reslit	-
penA	I515V	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	Penicillin	Reslit	-
penA	N512Y	-	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	Ceftriaxone\|CefiximeCEPHALOSPORIN	ReslitReference Gene Catalog	-
penA	T483S	-	reduced reactivity for β-lactams	Neisseria gonorrhoeae, Neisseria meningitidis	Ceftriaxone\|Cefixime	Reslit	-
penA	A516G	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	CEPHALOSPORIN	Reference Gene Catalog	-