Key Findings

The study identifies a cfr(B) variant in Enterococcus faecium clinical isolates that confers linezolid and chloramphenicol resistance. The cfr(B) gene is located on the transposon Tn6218 and shows high similarity to cfr from Clostridium difficile. Despite experimental efforts, the cfr(B) variant did not consistently confer resistance in transformant strains.