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Explore scientific publications on antimicrobial resistance
Explore scientific publications on antimicrobial resistance
Key Findings
The study identifies two novel genes, tetA(60) and tetB(60), which encode a heterodimeric ABC transporter responsible for tetracycline and tigecycline resistance in E. coli. The resistance mechanism involves the combined action of both genes, and the transporter exhibits a fitness cost in the host.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| tetA(60) | 1 | ABC half transporter | TetracyclineTigecyclineTETRACYCLINETIGECYCLINEDOXYCYCLINE |
| Card DatabaseReference Gene CatalogResFinder DatabaseReslit | - |
| tetB(60) | 1 | tetracycline efflux ABC transporter Tet(60) subunit B, ATP-binding cassette (ABC) antibiotic efflux pump | TETRACYCLINE |
|
Card DatabaseReference Gene CatalogResFinder DatabaseReslit |
| - |
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