Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux Activity.

PMID: 287397872017

Key Findings

The study identifies the role of blaKPC-3 and blaSHV-12 beta-lactamase genes, along with the T333N mutation in OmpK36, in conferring resistance to ceftazidime-avibactam in a porin-deficient strain of Klebsiella pneumoniae with increased efflux activity.

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2gene entries

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaKPC	1	beta-lactamase	CeftazidimeMeropenem	Klebsiella pneumoniae	Reslit	-
blaSHV	1	beta-lactamase	Ceftazidime	Klebsiella pneumoniae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ompK36	T333N	-	outer membrane porin OmpK36	Klebsiella pneumoniae	CARBAPENEM	Reference Gene Catalog	-

Browse Papers

Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux Activity.

AMR Genes

AMR Mutations