Whole genome sequencing, molecular typing and in vivo virulence of OXA-48-producing Escherichia coli isolates including ST131 H30-Rx, H22 and H41 subclones.

PMID: 289358732017Europe|Oviedo

Key Findings

The study characterizes the AMR genes and mutations in OXA-48-producing E. coli isolates, identifying blaOXA-48 as a key carbapenem resistance gene and highlighting fluoroquinolone resistance mutations in gyrA and parC.

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1gene entry

3mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaOXA	1	carbapenem-hydrolysing class D beta-lactamase	Carbapenem	Escherichia coli	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parC	E84V	-	-	-	Ciprofloxacin	Reslit	-
gyrA	S83L	-	-	Escherichia coli	Ciprofloxacin	Reslit	-
parC	S80I	-	-	-	Ciprofloxacin	Reslit	-

Browse Papers

Whole genome sequencing, molecular typing and in vivo virulence of OXA-48-producing Escherichia coli isolates including ST131 H30-Rx, H22 and H41 subclones.

AMR Genes

AMR Mutations