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Key Findings
The rpoB R201H mutation was identified in CRO RS isolates and confirmed to confer resistance through transformation experiments.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| R201H | - | DNA-directed RNA polymerase subunit beta RpoB | Neisseria gonorrhoeae | CeftriaxoneCEPHALOSPORIN | ReslitReference Gene Catalog | - | |
| E98K | - | RNA polymerase sigma factor RpoD | Neisseria gonorrhoeae | CeftriaxoneCEPHALOSPORIN | ReslitReference Gene Catalog | - | |
| DDDA92del | - | RNA polymerase sigma factor RpoD | Neisseria gonorrhoeae | CEPHALOSPORIN | Reference Gene Catalog | - | |
| P157L | - | DNA-directed RNA polymerase subunit beta RpoB | Neisseria gonorrhoeae | CEPHALOSPORIN | Reference Gene Catalog | - | |
| G158V | - | DNA-directed RNA polymerase subunit beta RpoB | Neisseria gonorrhoeae | CEPHALOSPORIN | Reference Gene Catalog | - |
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