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A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa.

PMID: 329667622021

Key Findings

Mutations in the switch loop and substrate binding sites affect efflux activity.

0gene entries

5mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
triC	R603A	-	partial loss in the ability to confer triclosan resistance (2 to 4 fold MIC decrease in comparison to WT) and was matched by a partial loss of Nile Red efflux	Pseudomonas aeruginosa	Triclosan	Reslit	-
triC	Q181A	-	more than 8-fold decrease in the MIC (minimal inhibitory concentration) of triclosan, a decrease in the ability to expel Nile Red, and a concurrent the loss of protection against SDS	Pseudomonas aeruginosa	Triclosan	Reslit	-
triC	G598V	-	reduction of Nile Red efflux by TriABC and obliterated the TriABC-dependent resistance to SDS and triclosan	Pseudomonas aeruginosa	Triclosan	Reslit	-
triC	V698R	-	inactive in MIC measurements and Nile Red uptake assays	Pseudomonas aeruginosa	Triclosan	Reslit	-
triC	S276A	-	active in efflux of Nile Red and displayed resistance to triclosan but could only partially complement the SDS susceptibility of efflux-deficient Δ9 cells	Pseudomonas aeruginosa	Triclosan	Reslit	-