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Key Findings
All mutations were identified in PZA/POA-resistant Mtb strains.
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| K9A | - | decreased enzyme activity, enzymatically inactive | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| K7A | - | partially decreased enzyme activity | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| L132P | - | decreased enzyme activity | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| H11A | - | decreased enzyme activity, enzymatically inactive | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| T16A | - | partially decreased enzyme activity | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| P134S | - | decreased enzyme activity | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| T16S | - | partially decreased enzyme activity | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| D31E | - | partially decreased enzyme activity | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| E126A | - | decreased enzyme activity | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - | |
| H119N | - | decreased enzyme activity | Mycobacterium tuberculosis | Pyrazinamide | Reslit | - |
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