Insights Into Mutations Induced Conformational Changes and Rearrangement of Fe(2+) Ion in pncA Gene of Mycobacterium tuberculosis to Decipher the Mechanism of Resistance to Pyrazinamide.

PMID: 340952182021

Key Findings

All mutations are in the pncA gene, which encodes pyrazinamidase, and are associated with reduced PZA binding affinity and resistance.

0gene entries

4mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA	D49N	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	Y64S	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	W68G	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-
pncA	F94A	-	-	Mycobacterium tuberculosis	Pyrazinamide	Reslit	-