Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae.

PMID: 345185462021

Key Findings

OqxB is an RND efflux pump that contributes to fluoroquinolone resistance in Klebsiella pneumoniae and Escherichia coli. Functional studies showed that overexpression of oqxB increases MICs for fluoroquinolones, confirming its role in efflux.

View on PubMed

1gene entry

4mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
oqxB	1	RND efflux pump	Fluoroquinolone	Escherichia coli Klebsiella pneumoniae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
oqxB	R157A	C470A	reduced efflux liability for fluoroquinolone molecules	Klebsiella pneumoniae, Escherichia coli, Salmonella spp., Enterobacter cloacae	Fluoroquinolones	Reslit	-

Browse Papers

Structure and function relationship of OqxB efflux pump from Klebsiella pneumoniae.

AMR Genes

AMR Mutations