Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico and In Vitro Evidence.

PMID: 345894422021India

Key Findings

The study identifies aerobactin as a stable and functional marker for the identification of hypervirulent carbapenem-resistant Klebsiella pneumoniae (CR-hvKp), highlighting the instability of RmpA2 and the importance of molecular identification due to the limitations of phenotypic screening.

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3gene entries

5mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
arr	1	Aminoglycoside resistance protein	Aminoglycoside	Klebsiella pneumoniae	Reslit	-
blaOXA	1	Beta-lactamase	Carbapenem	Klebsiella pneumoniae	Reslit	-
sul1	1	Sulfonamide resistance protein	Sulfonamide	Klebsiella pneumoniae

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrB	R256G	-	-	-	Colistin	Reslit	-
pmrB	D150H	-	-	-	Colistin	Reslit	-
pmrA	A217V	-	-	Klebsiella pneumoniae	Colistin	Reslit	-

Browse Papers

Aerobactin Seems To Be a Promising Marker Compared With Unstable RmpA2 for the Identification of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae: In Silico and In Vitro Evidence.

AMR Genes

AMR Mutations