Molecular Mechanisms of Colistin Resistance in Klebsiella pneumoniae in a Tertiary Care Teaching Hospital.

PMID: 347655652021China

Key Findings

The study identified mcr-1 and mcr-8 genes as plasmid-mediated colistin resistance mechanisms in Klebsiella pneumoniae isolates, along with chromosomal mutations in pmrB contributing to colistin resistance.

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2gene entries

5mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
mcr-1	1	phosphoethanolamine (PEtN) transferase	Colistin	Klebsiella pneumoniae Escherichia coli J53AZ R	Reslit	-
mcr-8	1	phosphoethanolamine (PEtN) transferase	Colistin	Klebsiella pneumoniae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pmrB	T246A	-	-	Klebsiella pneumoniae	Colistin	Reslit	-
pmrB	R256G	-	-	Klebsiella pneumoniae	Colistin	Reslit	-
pmrB	M285L	-	-	Klebsiella pneumoniae	Colistin	Reslit

Browse Papers

Molecular Mechanisms of Colistin Resistance in Klebsiella pneumoniae in a Tertiary Care Teaching Hospital.

AMR Genes

AMR Mutations