Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to para-Aminosalicylic Acid in Mycobacterium tuberculosis.

PMID: 347802662022

Key Findings

Mutations in rv2172c lead to decreased methionine production and increased susceptibility to PAS.

0gene entries

2mutation entries

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Rv2172c	L214A	-	decreased methionine production	Mycobacterium tuberculosis	Para-aminosalicylic acid	Reslit	-
Rv2172c	R159N	-	decreased methionine production	Mycobacterium tuberculosis	Para-aminosalicylic acid	Reslit	-