A Natural Novel Mutation in the bla(NDM-5) Promoter Reducing Carbapenems Resistance in a Clinical Escherichia coli Strain.

PMID: 351381412022China

Key Findings

A natural mutation in the promoter of blaNDM-5 in a clinical E. coli strain reduces carbapenem resistance by decreasing gene expression.

1gene entry

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaNDM	1	beta-lactamase	Carbapenem	Escherichia coli	Reslit	-

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
blaNDM-5	-	G5561A	reduces blaNDM-5 expression, leading to decreased carbapenem resistance	Escherichia coli	Carbapenem	Reslit	-