Drug Repurposing of the Unithiol: Inhibition of Metallo-β-Lactamases for the Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections.

PMID: 351637562022

Key Findings

Unithiol was identified as a competitive inhibitor of metallo-beta-lactamases NDM-1 and VIM-2, demonstrating effective inhibition of carbapenem resistance in clinical isolates of Klebsiella pneumoniae and Pseudomonas aeruginosa.

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2gene entries

0mutation entries

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaNDM	1	metallo-beta-lactamase	Carbapenem	Klebsiella pneumoniae Pseudomonas aeruginosa	Reslit	-
blaVIM	1	metallo-beta-lactamase	Carbapenem	Pseudomonas aeruginosa	Reslit	-

Browse Papers

Drug Repurposing of the Unithiol: Inhibition of Metallo-β-Lactamases for the Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections.

AMR Genes