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Explore scientific publications on antimicrobial resistance
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Key Findings
The study identifies a novel gene, dfrL, which encodes a DHFR with ~35% identity to native and known resistant DHFRs, and is associated with high-level resistance to trimethoprim and iclaprim. Additionally, various mutations in dfrB and folP were found to confer resistance to trimethoprim and sulfamethoxazole, respectively.
| Gene Name | Alleles | Encodes | Confers Resistance To | Organisms | Database | Validation Status |
|---|---|---|---|---|---|---|
| dfrL | 1 | dihydrofolate reductase (DHFR) | TrimethoprimTRIMETHOPRIM |
| Reference Gene CatalogReslit | - |
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
| L25I | - | dihydrofolate reductase DfrB | Staphylococcus aureus | TRIMETHOPRIM | Reference Gene Catalog | - | |
| F99Y | - | dihydrofolate reductase DfrB | Staphylococcus aureus | TRIMETHOPRIM | Reference Gene Catalog | - | |
| A135T | - | dihydrofolate reductase DfrB | Staphylococcus aureus | TRIMETHOPRIM |
Reference Gene Catalog |
| - |
| L41F | - | dihydrofolate reductase DfrB | Staphylococcus aureus | TRIMETHOPRIM | Reference Gene Catalog | - |
| H150R | - | dihydrofolate reductase DfrB | Staphylococcus aureus | TRIMETHOPRIM | Reference Gene Catalog | - |
| A184V | - | dihydropteroate synthase FolP | Staphylococcus aureus | SULFONAMIDE | Reference Gene Catalog | - |
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