Genotypic Evolution of Klebsiella pneumoniae Sequence Type 512 during Ceftazidime/Avibactam, Meropenem/Vaborbactam, and Cefiderocol Treatment, Italy.

PMID: 378775472023Italy

Key Findings

The study identifies a novel KPC-154 beta-lactamase and a nonsense mutation in the cirA gene contributing to cefiderocol resistance in Klebsiella pneumoniae ST512. Additionally, a deletion in the ompK36 gene was linked to reduced meropenem/vaborbactam susceptibility.

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4gene entries

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaKPC	1	beta-lactamase	Ceftazidime/avibactamCEPHALOSPORIN	Klebsiella pneumoniae Escherichia coli Klebsiella pneumoniae subsp. pneumoniae	Card DatabaseReference Gene CatalogReslit	-
cirA	1	iron transporter	Cefiderocol	Klebsiella pneumoniae	Reslit	-

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
cirA	E133Ter	-	catecholate siderophore receptor CirA	Klebsiella pneumoniae	CEFIDEROCOL	Reference Gene Catalog	-

Browse Papers

Genotypic Evolution of Klebsiella pneumoniae Sequence Type 512 during Ceftazidime/Avibactam, Meropenem/Vaborbactam, and Cefiderocol Treatment, Italy.

AMR Genes

AMR Mutations