Investigation of Citrobacter freundii clinical isolates in a Chinese hospital during 2020-2022 revealed genomic characterization of an extremely drug-resistant C. freundii ST257 clinical strain GMU8049 co-carrying bla(NDM-1) and a novel bla(CMY) variant.

PMID: 393875912024China

Key Findings

The study identified an extremely drug-resistant C. freundii strain GMU8049 co-carrying bla(NDM-1) and a novel bla(CMY) variant, along with a mutation in ompK37 contributing to carbapenem resistance.

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4gene entries

1mutation entry

AMR Genes

Gene Name	Alleles	Encodes	Confers Resistance To	Organisms	Database	Validation Status
blaCMY	2	AmpC beta-lactamase	Ceftazidime-avibactamCephalosporin	Citrobacter freundii GMU8049 Citrobacter freundii	Reslit	-
blaNDM	2	carbapenemase	AztreonamCefepimeCeftazidimeCeftriaxoneImipenemMeropenemErtapenemPiperacillin/tazobactam

AMR Mutations

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ompK37	N106S	-	-	Citrobacter freundii	Carbapenem	Reslit	-

Browse Papers

Investigation of Citrobacter freundii clinical isolates in a Chinese hospital during 2020-2022 revealed genomic characterization of an extremely drug-resistant C. freundii ST257 clinical strain GMU8049 co-carrying bla(NDM-1) and a novel bla(CMY) variant.

AMR Genes

AMR Mutations